When dealing with a patient experiencing seizures after substance use, which substance is least likely to be responsible?

The correct choice is based on the properties and effects of the substances listed. Marijuana is generally considered to have a lower association with seizures compared to the other substances.

Cocaine, alcohol, and LSD each have characteristics that can trigger seizure activity. Alcohol withdrawal, for instance, is well-documented as a significant cause of seizures, particularly in individuals with severe dependence. Cocaine can lead to increased central nervous system excitability, which may contribute to seizure disorders in certain users, especially during overdose or withdrawal scenarios. LSD, while primarily a hallucinogenic drug, can also result in seizures, although this is less common than with alcohol or cocaine.

Marijuana, on the other hand, has been studied more for its potential therapeutic benefits, including some anticonvulsant properties that can actually help in seizure management. Therefore, it is the least likely among the four to cause seizures in the context of substance use, making it the appropriate choice in this scenario.